HDAC6-IN-6
CAT:
804-HY-146679
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
HDAC6-IN-6
- CAS Number: 2413603-10-6
- UNSPSC Description: HDAC6-IN-6 (compound 6a) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-6 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-6 can enhance neurite outgrowth without significant neurotoxicity[1].
- Target Antigen: Amyloid-β; Cholinesterase (ChE); HDAC
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Epigenetics;Neuronal Signaling
- Applications: Neuroscience-Neurodegeneration
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/hdac6-in-6.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(C1=CC=C(C=C1)NC2=C3C=CC=CC3=NC4=CC=CC=C42)NO
- Molecular Weight: 329.35
- References & Citations: [1]Tseng HJ, et al. Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease. Eur J Med Chem. 2020 Apr 15;192:112193.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported