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HDAC6-IN-6

CAT: 0931-T60954-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T60954-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2413603-10-6
Target
Others, Beta Amyloid, Cholinesterase (ChE), HDAC
Related Pathways
Others, Chromatin/Epigenetic, Neuroscience, DNA Damage/DNA Repair
Bioactivity
HDAC6-IN-6 (compound 6a) is a potent HDAC6 inhibitor with an IC50 value of 0.025 μM that can penetrate the BBB. It exhibits strong inhibitory activity against AChE and Aβ 1-42 self-aggregation with IC50 values of 0.72 and 3.0 μM, respectively. HDAC6-IN-6 also enhances neurite outgrowth without significant neurotoxicity [1].
Smiles
N(C=1C2=C(N=C3C1C=CC=C3)C=CC=C2)C4=CC=C(C(NO)=O)C=C4
Molecular Formula
C20H15N3O2
Molecular Weight
329.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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