HDAC6-IN-8

• Description:

  A variety of compounds were designed and synthesized by modifying cap groups. The enzyme inhibition test showed that compound 12C had broad-spectrum enzyme inhibitory activity, and compounds 9m and 9q were more inclined to inhibit HDAC6, showing a certain selective inhibitory activity among the representative subtypes.

• UNSPSC:

  12352005

• Target:

  HDAC

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hdac6-in-8.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=CC=C2N=CN=C(C2=C1)NC3=CC(F)=C(C=C3)Br)CC4=CC=C(C=C4)C(NO)=O

• Molecular Formula:

  C23H17BrFN5O3

• Molecular Weight:

  510.32

• References & Citations:

  [1]Li X, et al. Design, Synthesis, and biological evaluation of HDAC6 inhibitors based on Cap modification strategy. Bioorg Chem. 2022 May 24;125:105874.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2796282-49-8]