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HDAC6-IN-47

CAT: 0804-HY-163834Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163834Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC6-IN-47 (Compound S-29b) is inhibitor for HDAC, which exhibits high affinities to HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 with Ki of 60, 56, 162, 0.44, 362 and 849 nM, respectively. HDAC6-IN-47 causes tubulin hyperacetylation in MV4-11, inhibits the proliferation of MV4-11 with an EC50 of 0.50 µM. HDAC6-IN-47 can be used in research of leukemia[1].
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac6-in-47.html
Smiles
O=C(C1=CC=C(C=C1)CN2C(CN3C(N4C)=O)=C(C5=C2C=CC(OCCN6CCOCC6)=C5)[C@@](C)(C3)C4=O)NO
Molecular Formula
C29H33N5O6
Molecular Weight
547.60
References & Citations
[1]Scheuerer S, et al. Biological and structural investigation of tetrahydro-β-carboline-based selective HDAC6 inhibitors with improved stability[J]. European Journal of Medicinal Chemistry, 2024: 116676.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC10; HDAC2; HDAC3; HDAC6; HDAC8

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