CRM1-IN-1

CAT: 0804-HY-155972Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-155972Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

CRM1-IN-1 (Compound KL1) is a noncovalent CRM1 inhibitor. CRM1-IN-1 induces nuclear CRM1 degradation (IC50: 0.27 μM) . CRM1-IN-1 inhibits CRM1-mediated nuclear export and cell proliferation, and triggers apoptosis in colorectal cancer cells[1].

UNSPSC

12352005

Target

CRM1

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/crm1-in-1.html

Solubility

10 mM in DMSO

Smiles

[H][C@]1([C@H](N)/C=C/C=C(C)/C[C@@H](C)/C=C(\C=C\[C@@]([H])(C[C@H](N)CC(OC)=O)O)C)O[C@@]([H])(/C=C/C)[C@@H](C)[C@@H](O)C1

Molecular Formula

C29H48N2O5

Molecular Weight

504.70

References & Citations

[1]Jian L, et al. Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J Med Chem. 2023 Aug 18.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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Catalog	Name
T79654-01	CRM1-IN-1
MBS5803144	CRM1 degrader 1
sc-74454	CRM1 (C-1)
MBS8565759-01	CRM1
sc-74454 AC	CRM1 (C-1) AC
sc-74454 FITC	CRM1 (C-1) FITC
sc-74454 HRP	CRM1 (C-1) HRP
sc-74454 PE	CRM1 (C-1) PE
DF13364-BP	CRM1 Peptide
MBS5821316	CRM1-IN-2

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