CRM1-IN-1

CRM1-IN-1

• UNSPSC Description: CRM1-IN-1 (Compound KL1) is a noncovalent CRM1 inhibitor. CRM1-IN-1 induces nuclear CRM1 degradation (IC50: 0.27 μM). CRM1-IN-1 inhibits CRM1-mediated nuclear export and cell proliferation, and triggers apoptosis in colorectal cancer cells[1].
• Target Antigen: CRM1
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/crm1-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: [H][C@]1([C@H](N)/C=C/C=C(C)/C[C@@H](C)/C=C(\C=C\[C@@]([H])(C[C@H](N)CC(OC)=O)O)C)O[C@@]([H])(/C=C/C)[C@@H](C)[C@@H](O)C1
• Molecular Weight: 504.70
• References & Citations: [1]Jian L, et al. Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J Med Chem. 2023 Aug 18.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported