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CRM1-IN-2

CAT: 0804-HY-155972ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155972ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CRM1-IN-2 (Compound KL2) is a noncovalent CRM1 inhibitor. CRM1-IN-2 localizes CRM1 in the nuclear periphery, depletes nuclear CRM1, and inhibits CRM1-mediated nuclear export. CRM1-IN-2 inhibits growth of colorectal cancer cells, and induces apoptosis[1].
UNSPSC
12352005
Target
Apoptosis; CRM1
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/crm1-in-2.html
Solubility
10 mM in DMSO
Smiles
[H][C@]1([C@@H](N)/C=C/C=C(C)/C[C@@H](C)/C=C(\C=C\[C@@]([H])(C[C@H](N)CC(OC)=O)O)C)O[C@@]([H])(/C=C/C)[C@@H](C)[C@@H](O)C1
Molecular Formula
C29H48N2O5
Molecular Weight
504.70
References & Citations
[1]Jian L, et al. Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J Med Chem. 2023 Aug 18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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