CRM1-IN-2

• UNSPSC Description:

  CRM1-IN-2 (Compound KL2) is a noncovalent CRM1 inhibitor. CRM1-IN-2 localizes CRM1 in the nuclear periphery, depletes nuclear CRM1, and inhibits CRM1-mediated nuclear export. CRM1-IN-2 inhibits growth of colorectal cancer cells, and induces apoptosis[1].

• Target Antigen:

  Apoptosis; CRM1

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Membrane Transporter/Ion Channel

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/crm1-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [H][C@]1([C@@H](N)/C=C/C=C(C)/C[C@@H](C)/C=C(\C=C\[C@@]([H])(C[C@H](N)CC(OC)=O)O)C)O[C@@]([H])(/C=C/C)[C@@H](C)[C@@H](O)C1

• Molecular Weight:

  504.70

• References & Citations:

  [1]Jian L,et al. Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J Med Chem. 2023 Aug 18.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported