Mt KARI-IN-5

Mt KARI-IN-5

• CAS Number: 2413974-69-1
• UNSPSC Description: Mt KARI-IN-5 (compound 6c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 4.72 μM. Mt KARI-IN-5 has inhibitory activity against Mtb H37Rv (MIC = 1.56 μM) and low cytotoxicity (HEK IC50 > 64 μg/mL)[1]
• Target Antigen: Bacterial
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/mt-kari-in-5.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C1=CC=C(C=C1)S(=O)(NC2=NN=C(S2)C3=CC=C(S3)[N+]([O-])=O)=O)=O
• Molecular Weight: 410.45
• References & Citations: [1]Krishna VS, et al. Design and development of ((4-methoxyphenyl)carbamoyl) (5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl)amide analogues as Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors. Eur J Med Chem. 2020;193:112178.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported