MT-3014

• Description :

  MT-3014 is a potent, highly selective and brain-penetrated phosphodiesterase 10A (PDE 10A) inhibitor, with IC50s of 0.062 nM and 0.09 nM for human PDE 10A and bovine PDE 10A, respectively[1].

• UNSPSC :

  12352005

• Target :

  Phosphodiesterase (PDE)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/mt-3014.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(O)(C)CNC1=CC(N2C[C@H](F)CC2)=NC3=CC(C4=NC5=CC(F)=CC=C5N=C4C)=NN13

• Molecular Formula :

  C23H25F2N7O

• Molecular Weight :

  453.49

• References & Citations :

  [1]Koizumi Y, et al. Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety. Bioorg Med Chem. 2019 Jun 19.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PDE10

• CAS Number :

  [1332727-40-8]