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KARI 201 (hydrochloride)

CAT: 0804-HY-171962A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-171962A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KARI 201 hydrochloride is a selective, brain penetrant pand competitive acid sphingomyelinase (ASM) inhibitor with an IC50 of 338.3?nM. KARI 201 hydrochloride is a ghrelin receptor agonist. KARI 201 hydrochloride improves neuropathological features of Alzheimer's disease[1].
CAS Number
2376132-24-8
UNSPSC
12352005
Target
GHSR; Phospholipase
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC(CO)(CO)C(N=N1)=CN1CCCCCCCCC.Cl
Molecular Formula
C14H29ClN4O2
Molecular Weight
320.86
References & Citations
[1]Park MH, et al. Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer's disease mice. Proc Natl Acad Sci U S A. 2022 Jan 18;119 (3) :e2115082119.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

2-amino-2-(1-nonyl-1H-1,2,3-triazol-4-yl)propane-1,3-diol hydrochloride
CAS Number2376132-24-8
PubChem CID153357652
IUPAC Name2-amino-2-(1-nonyltriazol-4-yl)propane-1,3-diol;hydrochloride
Molecular FormulaC14H29ClN4O2
Molecular Weight320.86
Topological Polar Surface Area97.2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count11
Heavy Atom Count21
Formal Charge0
Complexity249
SMILES
CCCCCCCCCN1C=C(N=N1)C(CO)(CO)N.Cl
InChI
InChI=1S/C14H28N4O2.ClH/c1-2-3-4-5-6-7-8-9-18-10-13(16-17-18)14(15,11-19)12-20;/h10,19-20H,2-9,11-12,15H2,1H3;1H
InChIKey
HOTAZHVFANOVID-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-amino-2-(1-nonyl-1H-1,2,3-triazol-4-yl)propane-1,3-diol hydrochloride
CAS: 2376132-24-8
CID: 153357652
Formula: C14H29ClN4O2
MW: 320.86
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight320.86
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count11
Exact Mass320.1979039
Monoisotopic Mass320.1979039
Topological Polar Surface Area97.2 Ų
Heavy Atom Count21
Formal Charge0
Complexity249
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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