Mt KARI-IN-2

• Description:

  Mt KARI-IN-2 (compound 5b) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 2.02 μM. Mt KARI-IN-2 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC50 > 86 μg/mL) [1].

• UNSPSC:

  12352005

• Target:

  Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/mt-kari-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC=C (C=C1) NC (NC2=NN=C (S2) C3=CC=C (O3) [N+] ([O-]) =O) =S

• Molecular Formula:

  C14H11N5O4S2

• Molecular Weight:

  377.40

• References & Citations:

  [1]Krishna VS, et al. Design and development of ((4-methoxyphenyl) carbamoyl) (5- (5-nitrothiophen-2-yl) -1,3,4-thiadiazol-2-yl) amide analogues as Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors. Eur J Med Chem. 2020;193:112178.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2413974-52-2