KARI 201

• Description:

  KARI 201 is a selective, brain penetrant pand competitive acid sphingomyelinase (ASM) inhibitor with an IC50 of 338.3?nM. KARI 201 is a ghrelin receptor agonist. KARI 201 improves neuropathological features of Alzheimer's disease[1].

• UNSPSC:

  12352005

• Target:

  GHSR; Phospholipase

• Related Pathways:

  GPCR/G Protein; Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Smiles:

  NC (CO) (CO) C (N=N1) =CN1CCCCCCCCC

• Molecular Formula:

  C14H28N4O2

• Molecular Weight:

  284.40

• References & Citations:

  [1]Park MH, et al. Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer's disease mice. Proc Natl Acad Sci U S A. 2022 Jan 18;119 (3) :e2115082119.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2376132-22-6