KARI 201

• Description :

  KARI 201 is a selective, brain penetrant pand competitive acid sphingomyelinase (ASM) inhibitor with an IC50 of 338.3?nM. KARI 201 is a ghrelin receptor agonist. KARI 201 improves neuropathological features of Alzheimer's disease[1].

• UNSPSC :

  12352005

• Target :

  GHSR; Phospholipase

• Related Pathways :

  GPCR/G Protein; Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Smiles :

  NC(CO)(CO)C(N=N1)=CN1CCCCCCCCC

• Molecular Formula :

  C14H28N4O2

• Molecular Weight :

  284.40

• References & Citations :

  [1]Park MH, et al. Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer's disease mice. Proc Natl Acad Sci U S A. 2022 Jan 18;119 (3) :e2115082119.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2376132-22-6]