hCAIX-IN-12

hCAIX-IN-12

• CAS Number: 2414598-85-7
• UNSPSC Description: hCAIX-IN-12 is a potent hCAIX inhibitor with IC50 values of 0.74, 10.78 μM for CAIX and CAII, respectively. hCAIX-IN-12 shows antiproliferative effect and induces apoptosis. hCAIX-IN-12 increases ROS production. hCAIX-IN-12 has the potential for the research of colorectal cancer (CRC) [1].
• Target Antigen: Apoptosis; Carbonic Anhydrase; Reactive Oxygen Species
• Type: Reference compound
• Related Pathways: Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hcaix-in-12.html
• Solubility: 10 mM in DMSO
• Smiles: O=S(C1=CC=C(N)C=C1)(NC2=C(C3=NC(C4=CC=CC=C4)=NO3)SC=C2)=O
• Molecular Weight: 398.46
• References & Citations: [1]Shamsi F, et al. Synthesis and SAR studies of novel 1,2,4-oxadiazole-sulfonamide based compounds as potential anticancer agents for colorectal cancer therapy. Bioorg Chem. 2020 May;98:103754.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported