JAK2/TYK2-IN-1

JAK2/TYK2-IN-1

• CAS Number: 2613434-12-9
• UNSPSC Description: JAK2/TYK2-IN-2 is a potent and selective TYK2 inhibitor with IC50 values of 9 and 157 nM for TYK2 and JAK2, respectively. JAK2/TYK2-IN-2 has anti-inflammatory activity[1].
• Target Antigen: JAK
• Type: Inhibitory Antibodies
• Related Pathways: Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/jak2-tyk2-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: N#CCCN1N=CC(C2=NC(NC3=CC4=C(N(S(=O)(C(F)(F)F)=O)C=C4)C=C3)=NC=C2F)=C1
• Molecular Weight: 479.41
• References & Citations: [1]Zhang C, et al. Discovery of 3-(4-(2-((1H-Indol-5-yl) amino)-5-fluoropyrimidin-4-yl)-1H-pyrazol-1-yl) propanenitrile Derivatives as Selective TYK2 Inhibitors for the Treatment of Inflammatory Bowel Disease. J Med Chem. 2021; 64(4):1966-1988.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported