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JAK2/TYK2-IN-1

CAT: 0804-HY-143884Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-143884Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JAK2/TYK2-IN-2 is a potent and selective TYK2 inhibitor with IC50 values of 9 and 157 nM for TYK2 and JAK2, respectively. JAK2/TYK2-IN-2 has anti-inflammatory activity[1].
CAS Number
2613434-12-9
UNSPSC
12352005
Target
JAK
Type
Inhibitory Antibodies
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jak2-tyk2-in-1.html
Solubility
10 mM in DMSO
Smiles
N#CCCN1N=CC(C2=NC(NC3=CC4=C(N(S(=O)(C(F)(F)F)=O)C=C4)C=C3)=NC=C2F)=C1
Molecular Formula
C19H13F4N7O2S
Molecular Weight
479.41
References & Citations
[1]Zhang C, et al. Discovery of 3- (4- (2- ((1H-Indol-5-yl) amino) -5-fluoropyrimidin-4-yl) -1H-pyrazol-1-yl) propanenitrile Derivatives as Selective TYK2 Inhibitors for the Treatment of Inflammatory Bowel Disease. J Med Chem. 2021; 64 (4) :1966-1988.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK2; Tyk2

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