LRRK2/NUAK1/TYK2-IN-1

LRRK2/NUAK1/TYK2-IN-1

• CAS Number: 2629192-96-5
• UNSPSC Description: LRRK2/NUAK1/TYK2-IN-1 (conpound 226) shows inhibitory activity toward LRRK2 (Wt), LRRK2 (G2019), TYK2 and NUAK1, with IC50 values lower than 10 nM. LRRK2/NUAK1/TYK2-IN-1 can be used for autoimmune disease research[1].
• Target Antigen: AMPK; JAK; LRRK2
• Type: Reference compound
• Related Pathways: Autophagy;Epigenetics;JAK/STAT Signaling;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/lrrk2-nuak1-tyk2-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: FC1=CC=CC(F)=C1C2=NC3=C(C4=NNC=C4N2)C=C(F)C(C5=CC=NN=C5)=C3
• Molecular Weight: 392.34
• References & Citations: [1]Roland Koestler, et al. 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as lrrk2, nuak1 and/or tyk2 kinase modulators for the treatment of e.g. autoimmune disease. Patent WO2021048618A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported