TYK2 JH2-IN-1-d3

• UNSPSC Description:

  TYK2 JH2-IN-1-d3 is the a deuterated, orally active and selective TYK2 inhibitor (compound 4h), targeting to JH2 domain (IC50=0.1 nM)[1].

• Target Antigen:

  JAK

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=CN=C(C2=C(OC)C(NC3=C(C(NC([2H])([2H])[2H])=O)N=NC(NC4=NC=C(C(C)(C)O)C=C4)=C3)=NC=C2)N=C1

• Molecular Weight:

  508.52

• References & Citations:

  [1]Xiao Z, et al. Structure-activity relationship study of central pyridine-derived TYK2 JH2 inhibitors: Optimization of the PK profile through C4' and C6 variations. Bioorg Med Chem Lett. 2023 Jul 15;91:129373.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2376999-19-6