TYK2 JH2-IN-1-d3
CAT:
804-HY-149892S
Size:
1 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
TYK2 JH2-IN-1-d3
- CAS Number: 2376999-19-6
- UNSPSC Description: TYK2 JH2-IN-1-d3 is the a deuterated, orally active and selective TYK2 inhibitor (compound 4h), targeting to JH2 domain (IC50=0.1 nM)[1].
- Target Antigen: JAK
- Type: Isotope-Labeled Compounds
- Related Pathways: Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Solubility: 10 mM in DMSO
- Smiles: FC1=CN=C(C2=C(OC)C(NC3=C(C(NC([2H])([2H])[2H])=O)N=NC(NC4=NC=C(C(C)(C)O)C=C4)=C3)=NC=C2)N=C1
- Molecular Weight: 508.52
- References & Citations: [1]Xiao Z, et al. Structure-activity relationship study of central pyridine-derived TYK2 JH2 inhibitors: Optimization of the PK profile through C4' and C6 variations. Bioorg Med Chem Lett. 2023 Jul 15;91:129373.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported