JAK1/2-IN-1

JAK1/2-IN-1

• CAS Number: 3023876-01-6
• UNSPSC Description: JAK1/2-IN-1 is a potent JAK1 and JAK2 inhibitor with IC50 values of 0.4 nM and 8.1 nM, respectively. JAK1/2-IN-1 also inhibits IL-4 and IL-13 with IC50s of 136.5 nM and 19.1 nM, respectively (WO2023244775A1; Example 33a)[1].
• Target Antigen: Interleukin Related; JAK
• Type: Reference compound
• Related Pathways: Epigenetics;Immunology/Inflammation;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/jak1-2-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=C(N=C(NC2=CC(C(F)(F)F)=C3C(COB3O)=C2)N=C1)N[C@H]4[C@H](C#N)CCOC4
• Molecular Weight: 433.19
• References & Citations: [1]Alan Long, et al. Boron containing pyrimidine compounds, compositions comprising them, methods and uses thereof. WO2023244775A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported