JAK1/2-IN-1

• UNSPSC Description:

  JAK1/2-IN-1 is a potent JAK1 and JAK2 inhibitor with IC50 values of 0.4 nM and 8.1 nM, respectively. JAK1/2-IN-1 also inhibits IL-4 and IL-13 with IC50s of 136.5 nM and 19.1 nM, respectively (WO2023244775A1; Example 33a)[1].

• Target Antigen:

  Interleukin Related; JAK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;Immunology/Inflammation;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/jak1-2-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=C(N=C(NC2=CC(C(F)(F)F)=C3C(COB3O)=C2)N=C1)N[C@H]4[C@H](C#N)CCOC4

• Molecular Weight:

  433.19

• References & Citations:

  [1]Alan Long, et al. Boron containing pyrimidine compounds, compositions comprising them, methods and uses thereof. WO2023244775A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3023876-01-6