PROTAC TYK2 degrader-1

• CAS Number:

  2770470-20-5

• UNSPSC Description:

  PROTAC TYK2 degrader-1 (CPD-155) is a PROTAC targeting degrader to TYK2 with Dmax >60%. (Structure Note: PINK, TYK2 ligand 1 (HY-158340); Blue, VHL ligand Thalidomide (HY-14658); Black, linker)

• Target Antigen:

  JAK; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;JAK/STAT Signaling;PROTAC;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-tyk2-degrader-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CNC(C1=NN=C(C=C1NC2=CC=CC(C3=NN(C=N3)C)=C2OC)NC4=NC=C(C=C4)C(NCCCCCNC5=CC=CC6=C5C(N(C6=O)C7CCC(NC7=O)=O)=O)=O)=O

• Molecular Weight:

  815.84

• References & Citations:

  [1]Jing Liu, et al. Tyrosine kinase 2 (tyk2) degradation compounds and methods of use. US20240059671A1. 2024-02-22.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported