HIV-1 protease-IN-2

• UNSPSC Description:

  HIV-1 protease-IN-2 is a potent HIV-1 protease inhibitor with an IC50 of 2.53 nM. HIV-1 protease-IN-2 shows antiviral activity against DRV (Darunavir)-sensitive or DRV-resistant HIV-1 variants[1].

• Target Antigen:

  HIV Protease

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Metabolic Enzyme/Protease

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/hiv-1-protease-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC=C(C=C1)S(=O)(N(C[C@H]([C@@H](NC(CN2C=CC(NC2=O)=O)=O)CC3=CC=CC=C3)O)CC(C)C)=O

• Molecular Weight:

  558.65

• References & Citations:

  [1]Zhu M, et al. Preliminary SAR and biological evaluation of potent HIV-1 protease inhibitors with pyrimidine bases as novel P2 ligands to enhance activity against DRV-resistant HIV-1 variants. Eur J Med Chem. 2020 Jan 1;185:111866.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2248124-46-9