HIV-1 protease-IN-2

HIV-1 protease-IN-2

• CAS Number: 2248124-46-9
• UNSPSC Description: HIV-1 protease-IN-2 is a potent HIV-1 protease inhibitor with an IC50 of 2.53 nM. HIV-1 protease-IN-2 shows antiviral activity against DRV (Darunavir)-sensitive or DRV-resistant HIV-1 variants[1].
• Target Antigen: HIV Protease
• Type: Reference compound
• Related Pathways: Anti-infection;Metabolic Enzyme/Protease
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/hiv-1-protease-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: COC1=CC=C(C=C1)S(=O)(N(C[C@H]([C@@H](NC(CN2C=CC(NC2=O)=O)=O)CC3=CC=CC=C3)O)CC(C)C)=O
• Molecular Weight: 558.65
• References & Citations: [1]Zhu M, et al. Preliminary SAR and biological evaluation of potent HIV-1 protease inhibitors with pyrimidine bases as novel P2 ligands to enhance activity against DRV-resistant HIV-1 variants. Eur J Med Chem. 2020 Jan 1;185:111866.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported