Trk-IN-9

• Description :

  Trk-IN-9 (Compound 12) is a potent inhibitor of TRK. Trk-IN-9 inhibits the proliferation of Km-12 cell lines. Trk-IN-9 induces the apoptosis of Km-12 cells in a concentration-dependent manner. Trk-IN-9 inhibits the phosphorylation of TRK to block downstream pathways. Trk-IN-9 has the potential for the research of NTRK-fusion cancers[1].

• UNSPSC :

  12352005

• Target :

  Trk Receptor

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/trk-in-9.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC1=CC=CC(CNC2=NC(NC3=CC(C(N[C@@H]4CCCNC4)=O)=CC=C3)=NC=C2Cl)=C1

• Molecular Formula :

  C23H24ClFN6O

• Molecular Weight :

  454.93

• References & Citations :

  [1]Wu T, et al. Rational drug design to explore the structure-activity relationship (SAR) of TRK inhibitors with 2,4-diaminopyrimidine scaffold. Eur J Med Chem. 2022;230:114096.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2758623-12-8]