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RIPK1-IN-11

CAT: 0804-HY-144276Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144276Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RIPK1-IN-11 is a potent and orally active RIPK1 inhibitor (Kd=9.2 nM; IC50=67 nM) . RIPK1-IN-11 inhibits necroptosis in both human and mouse cells (EC50=17-30 nM) . Anti-inflammatory activity[1].
CAS Number
2173557-02-1
UNSPSC
12352005
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ripk1-in-11.html
Solubility
10 mM in DMSO
Smiles
O=C(OC1CCOCC1)NC2=CC(C3=CC=C4N=C(NC(C5CC5)=O)SC4=C3)=CN=C2C
Molecular Formula
C23H24N4O4S
Molecular Weight
452.53
References & Citations
[1]Li Z, Hao Y, Yang C, et al. Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity. Eur J Med Chem. 2022;228:114036.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK1

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