EGFR-IN-40

CAT: 0804-HY-143901Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-143901Size:1 Each

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Description

EGFR-IN-40 (compound 3z) is a potent BTK, EGFR, and ITK inhibitor with IC50 values of 1.2 nM, 5.3 nM, and 46.1 nM, respectively[1].

CAS Number

1466445-39-5

UNSPSC

12352005

Target

Btk; EGFR; Itk

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-in-40.html

Solubility

10 mM in DMSO

Smiles

C=CC(NC1=CC=CC(N2C(C(C)=NC3=CN=C(NC4=CC=C(OC)C=C4)N=C23)=O)=C1)=O

Molecular Formula

C23H20N6O3

Molecular Weight

428.44

References & Citations

[1]Dou Dou, et al. Discovery of Pteridine-7 (8 H) -one Derivatives as Potent and Selective Inhibitors of Bruton's Tyrosine Kinase (BTK) . J Med Chem. 2022 Feb 10;65 (3) :2694-2709.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

EGFR/ErbB1/HER1

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T62343-01	EGFR-IN-40
AM11067SU-N	EGFR Mouse Monoclonal Antibody [Clone ID: 51CT78.40.5]
sc-80543	EGFR (EGFR.1)
ant-042	EGFR

EGFR-IN-40

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