QO-40

• Description :

  QO-40, a pyrazolo[1,5-a]pyrimidine-7 (4H) -one (PPO) derivative, is a KCNQ2/KCNQ3 K+ channels activator with an EC50 of 6.94 μM. QO-40 stimulated Ca2+-activated K+ current (IK (Ca) ) with an EC50 value of 2.3 μM in pituitary GH3 lactotrophs[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H318, H335

• Target :

  Potassium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/qo-40.html

• Purity :

  98.77

• Solubility :

  DMSO : ≥ 125 mg/mL

• Smiles :

  O=C1C=C(CCl)NC2=C(C3=C4C=CC=CC4=CC=C3)C(C(F)(F)F)=NN12

• Molecular Formula :

  C18H11ClF3N3O

• Molecular Weight :

  377.75

• Precautions :

  H302, H315, H318, H335

• References & Citations :

  [1]Jia C, et al. Activation of KCNQ2/3 potassium channels by novel pyrazolo[1,5-a]pyrimidin-7 (4H) -one derivatives. Pharmacology. 2011;87 (5-6) :297-310.|[2]Chang WT, et al. Effective Activation of BKCa Channels by QO-40 (5- (Chloromethyl) -3- (Naphthalen-1-yl) -2- (Trifluoromethyl) Pyrazolo [1,5-a]pyrimidin-7 (4H) -one), Known to Be an Opener of KCNQ2/Q3 Channels. Pharmaceuticals (Basel) . 2021 Apr 21;14 (5) :388.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1259536-70-3]