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Hsp90-IN-40

CAT: 0804-HY-171755Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-171755Size:1 Each
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Description
Hsp90-IN-40 (Compound 15b) is a heat shock protein 90 (Hsp90) C-terminal inhibitor. Hsp90-IN-40 exhibits antiproliferative activity against SKBr3 and MCF-7 breast cancer cells (IC50 of 2.57 µM and 2.43 µM, respectively) . Hsp90-IN-40 inhibits cancer cell growth by inhibiting the Hsp90 C-terminal function, leading to Hsp90-dependent protein degradation. Hsp90-IN-40 can be used in breast cancer research[1].
CAS Number
2169278-81-1
UNSPSC
12352005
Target
HSP
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
COC1=C(C2=CC(OC)=CC=C2)C=C(C=C1)C(N[C@@H]3CC[C@H](C4=CC=C(C=C4)OC5CCN(CC5)C)CC3)=O
Molecular Formula
C33H40N2O4
Molecular Weight
528.68
References & Citations
[1]Garg G, et al. Development of Phenyl Cyclohexylcarboxamides as a Novel Class of Hsp90 C-terminal Inhibitors. Chemistry. 2017 Nov 21;23 (65) :16574-16585.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90

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