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Wee1/HDAC-IN-1

CAT: 0804-HY-179272Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179272Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Wee1/HDAC-IN-1 is a  dual Wee1/HDAC inhibitor with an IC50 of 1.2 nM for Wee1 and IC50 values of 196 nM for HDAC1, 156 nM for HDAC3, and 55 nM for HDAC6. Wee1/HDAC-IN-1 exhibits strong antiproliferative activity against MV4-11 cells with an IC50 of 0.076 μM. Wee1/HDAC-IN-1 selectively binds to Wee1 and HDACs. Wee1/HDAC-IN-1 interferes with DNA damage repair pathways and induces apoptosis in MV4-11 cells.  Wee1/HDAC-IN-1  Wee1/HDAC-IN-1 can be used for the research of acute myeloid leukemia (AML) [1].
CAS Number
3037071-29-4
UNSPSC
12352005
Target
Apoptosis; HDAC; Wee1
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1N(N(C2=NC(NC3=CC=C(C=C3)N4CCN(CC4)CCCCCCC(NO)=O)=NC=C21)C5=NC(C(O)(C)C)=CC=C5)CC=C
Molecular Formula
C33H43N9O4
Molecular Weight
629.75
References & Citations
[1]Zhang W, et al. Discovery of Novel and Highly Potent Wee1 and HDAC Dual-Target Inhibitors for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2025;68 (21) :22845-22873.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC6; HDAC8

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