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HDAC-IN-27

CAT: 0804-HY-142690Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-142690Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC-IN-27 (Compound 11h) is a potent, orally active class I HDAC-selective inhibitor with IC50 values ranging from 0.43 to 3.01 nM against HDAC1-3. HDAC-IN-27 exhibits both in vivo and in vitro antitumor activity. HDAC-IN-27 demonstrates significant anti-proliferative activity against acute myeloid leukemia (AML) cell lines by inducing apoptosis and histone acetylation (AcHH3 and AcHH4) . HDAC-IN-27 can be used for research in acute myeloid leukemia (AML) [1].
CAS Number
2763368-89-2
UNSPSC
12352005
Target
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac-in-27.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC2=CC=CC=C2N1)NCC3=CC=C(C=C3)C(NNCCC)=O
Molecular Formula
C20H22N4O2
Molecular Weight
350.41
References & Citations
[1]Jiang Y, et al. Potent Hydrazide-Based HDAC Inhibitors with a Superior Pharmacokinetic Profile for Efficient Treatment of Acute Myeloid Leukemia In Vivo. J Med Chem. 2022;65 (1) :285-302.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3

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