PRMT5-IN-15

• Description:

  PRMT5-IN-15 is a PRMT5 inhibitor with an IC50 value of 0.84 nM.

• UNSPSC:

  12352005

• Target:

  Histone Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/prmt5-in-15.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=NC2=CC(C[C@@H]3CC[C@@]4([C@H]([C@@H](C[C@H]34)N5C=C(C6=C5N=CN=C6N)F)O)O)=CC(F)=C2C=C1F

• Molecular Formula:

  C24H23F3N6O2

• Molecular Weight:

  484.47

• References & Citations:

  [1]Quiroz RV, et al. The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer. J Med Chem. 2021 Apr 8;64 (7) :3911-3939.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PRMT5

• CAS Number:

  [2410637-87-3]