PRMT5-IN-15

CAT: 0804-HY-142211Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-142211Size:1 Each
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Description
PRMT5-IN-15 is a PRMT5 inhibitor with an IC50 value of 0.84 nM.
CAS Number
[2410637-87-3]
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/prmt5-in-15.html
Solubility
10 mM in DMSO
Smiles
NC1=NC2=CC(C[C@@H]3CC[C@@]4([C@H]([C@@H](C[C@H]34)N5C=C(C6=C5N=CN=C6N)F)O)O)=CC(F)=C2C=C1F
Molecular Formula
C24H23F3N6O2
Molecular Weight
484.47
References & Citations
[1]Quiroz RV, et al. The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer. J Med Chem. 2021 Apr 8;64 (7) :3911-3939.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT5

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