LP-284

• Description :

  LP-284 is a potent DNA alkylating agent that kills solid tumours. LP-284 can be used in the studies of hematologic cancers with compromised DNA repair, such as mantle cell lymphoma (MCL) [1][2].

• UNSPSC :

  12352211

• Target :

  DNA Alkylator/Crosslinker

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/lp-284.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C1(CC1)[C@@](O)(C)C2=O)=C3C2=CC(C)=C3CN(C(N)=O)O

• Molecular Formula :

  C16H20N2O4

• Molecular Weight :

  304.34

• References & Citations :

  [1]Zhou J, et al. MCL-319 LP-284 - A Highly Potent Small Molecule Targeting Mantle Cell Lymphoma. Clin Lymphoma Myeloma Leuk. 2022 Oct;22 Suppl 2:S396. |[2]Zhou J, et al. The Positive Enantiomer of a Novel Chiral DNA Alkylating Agent Exhibits Nanomolar Potency in Hematologic Cancers. Blood, 2021, 138: 3991.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [2412580-47-1]