LP-284

CAT: 0804-HY-139453ASize: 1 EachDry Ice: NoHazardous: No

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Description

LP-284 is a potent DNA alkylating agent that kills solid tumours. LP-284 can be used in the studies of hematologic cancers with compromised DNA repair, such as mantle cell lymphoma (MCL) [1][2].

CAS Number

2412580-47-1

UNSPSC

12352211

Target

DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lp-284.html

Solubility

10 mM in DMSO

Smiles

CC(C1(CC1)[C@@](O)(C)C2=O)=C3C2=CC(C)=C3CN(C(N)=O)O

Molecular Formula

C16H20N2O4

Molecular Weight

304.34

References & Citations

[1]Zhou J, et al. MCL-319 LP-284 - A Highly Potent Small Molecule Targeting Mantle Cell Lymphoma. Clin Lymphoma Myeloma Leuk. 2022 Oct;22 Suppl 2:S396. |[2]Zhou J, et al. The Positive Enantiomer of a Novel Chiral DNA Alkylating Agent Exhibits Nanomolar Potency in Hematologic Cancers. Blood, 2021, 138: 3991.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

Chemical Information

8A36NL8Cat

CAS Number	2412580-47-1
PubChem CID	153129765
IUPAC Name	1-hydroxy-1-[[(5'S)-5'-hydroxy-2',5',7'-trimethyl-4'-oxospiro[cyclopropane-1,6'-indene]-1'-yl]methyl]urea
Molecular Formula	C16H20N2O4
Molecular Weight	304.34
XLogP	-1.1
Topological Polar Surface Area	104
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Heavy Atom Count	22
Formal Charge	0
Complexity	697

SMILES

CC1=C(C2=C(C3(CC3)[C@](C(=O)C2=C1)(C)O)C)CN(C(=O)N)O

InChI

InChI=1S/C16H20N2O4/c1-8-6-10-12(11(8)7-18(22)14(17)20)9(2)16(4-5-16)15(3,21)13(10)19/h6,21-22H,4-5,7H2,1-3H3,(H2,17,20)/t15-/m1/s1

InChIKey

VWMPVAZEBAKLFR-OAHLLOKOSA-N

Chemical Structure

2D Structure

CAS: 2412580-47-1

CID: 153129765

Formula: C16H20N2O4

MW: 304.34

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	304.34
XLogP3	-1.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	304.14230712
Monoisotopic Mass	304.14230712
Topological Polar Surface Area	104 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	697
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-159482	SBN-284
HY-107777A-01	LLY-284
HY-19987-01	BML-284
HY-146697	IHMT-TRK-284
HY-178937	Anticancer agent 284
HY-174313	Antibacterial agent 284
HY-W999602	CRBN ligand-284
HY-19987R-01	BML-284 (Standard)
HY-19987A	BML-284 (hydrochloride)
HY-117626-01	LP-935509

Alternative Products

Catalog	Name
T60706-01	LP-284
MBS131522	BML-284 (BML 284; BML284)
T88928-01	SBN-284
C13440-25mg	LLY-284
C03358-5mg	BML-284

LP-284

Chemical Information

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