Antibacterial agent 284

CAT: 0804-HY-174313Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-174313Size:1 Each
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Description
Antibacterial agent 284 (Compound 7) is an Antibacterial agent. Antibacterial agent 284 has a zinc-binding structure and potent inhibitory activity against Legionella pneumophila metalloprotease ProA (IC50: 0.96 μM) with zinc-binding structure. Antibacterial agent 284 significantly inactivates the cleavage of collagen IV and flagellin (ProA substrates) and reduces immune evasion from the TLR5-NF-κB pathway and PMN-mediated inflammation in human lung tissue explants. Antibacterial agent 284 is promising for Legionnaires' disease research[1].
UNSPSC
12352005
Target
Bacterial; Collagen; Toll-like Receptor (TLR)
Related Pathways
Anti-infection; Cytoskeleton; Immunology/Inflammation
Field of Research
Infection; Inflammation/Immunology
Smiles
CC(CC(P(O)(O)=O)C(N[C@@H](C(C)C)C(NC1=CC=C(C(Cl)=C1)Cl)=O)=O)C
Molecular Formula
C17H25Cl2N2O5P
Molecular Weight
439.27
References & Citations
[1]Scheithauer L, et al. Innovative zinc-binding inhibitors of Legionella pneumophila ProA reduce collagen and flagellin degradation, TLR5 evasion, and human lung tissue inflammation. Eur J Med Chem. 2025 May 30;296:117832.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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