BML-284 (hydrochloride)

BML-284 (hydrochloride)

• CAS Number: 2095432-75-8
• UNSPSC Description: BML-284 hydrochloride is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50?of 700 nM[1].
• Target Antigen: Wnt
• Type: Reference compound
• Related Pathways: Stem Cell/Wnt
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/bml-284-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: NC1=NC(C2=CC=CC(OC)=C2)=CC(NCC3=CC=C(OCO4)C4=C3)=N1.[H]Cl
• Molecular Weight: 386.83
• References & Citations: [1]Liu J, et al. A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl. 2005 Mar 18;44(13):1987-90.|[2]Ying Jiang, et al. Pizotifen inhibits the proliferation and invasion of gastric cancer cells. Exp Ther Med. 2020 Feb;19(2):817-824.|[3]Yunlong Meng, et al. Exposure to pyrimethanil induces developmental toxicity and cardiotoxicity in zebrafish. Chemosphere. 2020 Sep;255:126889
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported