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SBN-284

CAT: 0804-HY-159482Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-159482Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SBN-284 (compound 3x) is a dual inhibitor of blood-brain permeable Cholinesterases and the NLRP3 inflammasome and is effective against EeAChE, hAChE and eqBChE, the IC50 values of are 0.37, 0.31, 0.29 μM respectively, and the EC50 of NLRP3 inflamm is 1 μM. SBN-284 can be used in Alzheimer's disease research[1].
UNSPSC
12352005
Target
Cholinesterase (ChE) ; NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sbn-284.html
Smiles
CC(N[C@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(NCCC4CCN(CC5=CC=CC=C5)CC4)C2=O)=O
Molecular Formula
C35H43N3O5
Molecular Weight
585.73
References & Citations
[1]Reddy CN, et al. Synthesis and Biological Evaluation of Colchicine─Aryl/Alkyl Amine Hybrids as Potential Noncytotoxic Cholinesterase Inhibitors: Identification of SBN-284 as a Dual Inhibitor of Cholinesterases and NLRP3 Inflammasome. ACS Chem Neurosci. 2024 Aug 7;15 (15) :2779-2794.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE; NLRP3

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