BML-284

• Description:

  BML-284 is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319

• Target:

  Wnt

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/BML-284.html

• Purity:

  99.99

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  NC1=NC (C2=CC=CC (OC) =C2) =CC (NCC3=CC=C (OCO4) C4=C3) =N1

• Molecular Formula:

  C19H18N4O3

• Molecular Weight:

  350.37

• Precautions:

  H315, H319

• References & Citations:

  [1]Liu J, et al. A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl. 2005 Mar 18;44 (13) :1987-90.|[2]Ying Jiang, et al. Pizotifen inhibits the proliferation and invasion of gastric cancer cells. Exp Ther Med. 2020 Feb;19 (2) :817-824.|[3]Yunlong Meng, et al. Exposure to pyrimethanil induces developmental toxicity and cardiotoxicity in zebrafish. Chemosphere. 2020 Sep;255:126889.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  853220-52-7