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IHMT-TRK-284

CAT: 0804-HY-146697Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146697Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IHMT-TRK-284 (Compound 34) is a potent, orally active type II TRK kinase inhibitor with IC50 values of 10.5, 0.7, and 2.6 nM to TRKA, B, and C respectively. IHMT-TRK-284 displays great selectivity profile in the kinome and good in vivo antitumor efficacies[1].
CAS Number
2416844-79-4
UNSPSC
12352005
Target
Apoptosis; Bcr-Abl; c-Fms; c-Kit; PDGFR; Trk Receptor
Type
Reference compound
Related Pathways
Apoptosis; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ihmt-trk-284.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NC(C)=C(C2=CC3=C(C=C2)C(/C=C/C4=NC=CC=C4)=NN3)S1)CN5CCN(C)CC5
Molecular Formula
C25H27N7OS
Molecular Weight
473.59
References & Citations
[1]Beilei Wang, et al. Discovery of (E) -N- (4-methyl-5- (3- (2- (pyridin-2-yl) vinyl) -1H-indazol-6-yl) thiazol-2-yl) -2- (4-methylpiperazin-1-yl) acetamide (IHMT-TRK-284) as a novel orally available type II TRK kinase inhibitor capable of overcoming multiple resistant mutants. Eur J Med Chem. 2020 Dec 1;207:112744.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Abl; PDGFRα; PDGFRβ; TrkA; TrkB; TrkC

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