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AhR modulator-1

CAT: 0804-HY-135671Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-135671Size:1 Each
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Description
AhR modulator-1 (compound 6-MCDF) is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. AhR modulator-1 inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. AhR modulator-1 also possess anti-estrogenic properties in rat uterus[1].
CAS Number
118174-38-2
UNSPSC
12352005
Target
Aryl Hydrocarbon Receptor; Estrogen Receptor/ERR; VEGFR
Type
Reference compound
Related Pathways
Immunology/Inflammation; Protein Tyrosine Kinase/RTK; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/ahr-modulator-1.html
Solubility
10 mM in DMSO
Smiles
CC1=C(OC2=CC(Cl)=CC(Cl)=C23)C3=CC(Cl)=C1
Molecular Formula
C13H7Cl3O
Molecular Weight
285.55
References & Citations
[1]Fritz WA, et al. The selective aryl hydrocarbon receptor modulator 6-methyl-1,3,8-trichlorodibenzofuran inhibits prostate tumor metastasis in TRAMP mice. Biochem Pharmacol. 2009 Apr 1;77 (7) :1151-60.|[2]Koliopanos A, et al. Increased arylhydrocarbon receptor expression offers a potential therapeutic target for pancreatic cancer. Oncogene. 2002 Sep 5;21 (39) :6059-70.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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