AhR modulator-1

• UNSPSC Description:

  AhR modulator-1 (compound 6-MCDF) is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. AhR modulator-1 inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. AhR modulator-1 also possess anti-estrogenic properties in rat uterus[1].

• Target Antigen:

  Aryl Hydrocarbon Receptor; Estrogen Receptor/ERR; VEGFR

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Protein Tyrosine Kinase/RTK;Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/ahr-modulator-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=C(OC2=CC(Cl)=CC(Cl)=C23)C3=CC(Cl)=C1

• Molecular Weight:

  285.55

• References & Citations:

  [1]Fritz WA, et al. The selective aryl hydrocarbon receptor modulator 6-methyl-1,3,8-trichlorodibenzofuran inhibits prostate tumor metastasis in TRAMP mice. Biochem Pharmacol. 2009 Apr 1;77(7):1151-60.|[2]Koliopanos A, et al. Increased arylhydrocarbon receptor expression offers a potential therapeutic target for pancreatic cancer. Oncogene. 2002 Sep 5;21(39):6059-70.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  118174-38-2