MGluR2 modulator 1

• Description :

  MGluR2 modulator 1 (compound 95) is a potent and BBB-penetrated mGluR2 (metabotropic glutamate receptor-2) positive allosteric modulator, with an EC50 of 0.03 μM. mGluR2 modulator 1 can be used for psychosis research[1].

• UNSPSC :

  12352005

• Target :

  MGluR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/mglur2-modulator-1.html

• Purity :

  98.0

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C1N(CCN2C1=NC3=C2C=CC=C3)CCCCOC4=CC=C(C=C4)OC(F)(F)F

• Molecular Formula :

  C21H20F3N3O3

• Molecular Weight :

  419.40

• References & Citations :

  [1]Szabó G, et al. Discovery of dihydropyrazino-benzimidazole derivatives as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators (PAMs) . Eur J Med Chem. 2020 Jan 15;186:111881.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MGluR2

• CAS Number :

  [2671063-84-4]