MGluR2 modulator 1

• Description:

  MGluR2 modulator 1 (compound 95) is a potent and BBB-penetrated mGluR2 (metabotropic glutamate receptor-2) positive allosteric modulator, with an EC50 of 0.03 μM. mGluR2 modulator 1 can be used for psychosis research[1].

• UNSPSC:

  12352005

• Target:

  MGluR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/mglur2-modulator-1.html

• Purity:

  98.0

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C1N (CCN2C1=NC3=C2C=CC=C3) CCCCOC4=CC=C (C=C4) OC (F) (F) F

• Molecular Formula:

  C21H20F3N3O3

• Molecular Weight:

  419.40

• References & Citations:

  [1]Szabó G, et al. Discovery of dihydropyrazino-benzimidazole derivatives as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators (PAMs) . Eur J Med Chem. 2020 Jan 15;186:111881.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MGluR2

• CAS Number:

  2671063-84-4