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HDAC3-IN-6

CAT: 0931-T205688-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205688-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
HDAC, ROS, PD-1/PD-L1, Apoptosis, Reactive Oxygen Species
Related Pathways
Apoptosis, NF-κB, Chromatin/Epigenetic, Metabolism, DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Immunology/Inflammation
Bioactivity
HDAC3-IN-6 (Compound SC26) is a selective HDAC3 inhibitor with an IC50 of 53 nM. It induces PD-L1 expression in a dose-dependent manner and leads to significant apoptosis and reactive oxygen species (ROS) production. HDAC3-IN-6 exhibits strong antitumor efficacy against colorectal cancer.
Smiles
CCCNNC(=O)C1=CC=C(C=C1)CNC(=O)C2=CN=C(N2)C3=CC4=C(C=C3)OC=C4
Molecular Formula
C23H23N5O3
Molecular Weight
417.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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