U-99194

• Description :

  U-99194 (PNU-99194) is a selective, potent dopamine D3 receptor antagonist. U-99194 inhibits the activation of D3 receptor mediated by endogenously released dopamine or exogenous D3 agonists. U-99194 abrogates the IPSC-suppressive effect of the D3 agonist PD 128907 in rat hippocampal slices. U-99194 significantly suppresses Nicotine (HY-127019) -induced tremor in mice. U-99194 can be used for the study of dopamine D3 receptor-mediated motor disorders, particularly kinetic tremors[1][2].

• Product Name Alternative :

  U-99194A (free base) ; PNU-99194A; JPC-211

• UNSPSC :

  12352005

• Target :

  Dopamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/u-99194.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCCN(CCC)C1CC2=C(C=C(OC)C(OC)=C2)C1

• Molecular Formula :

  C17H27NO2

• Molecular Weight :

  277.40

• References & Citations :

  [1]Kato M, et al. Mechanisms Underlying Dopaminergic Regulation of Nicotine-Induced Kinetic Tremor. Front Pharmacol. 2022 Jun 16;13:938175. |[2]Hammad H, et al. Dopamine-mediated disinhibition in the CA1 region of rat hippocampus via D3 receptor activation. J Pharmacol Exp Ther. 2006 Jan;316 (1) :113-20.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  D3 Receptor

• CAS Number :

  [82668-33-5]