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U-99194

CAT: 0804-HY-12701Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12701Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
U-99194 (PNU-99194) is a selective, potent dopamine D3 receptor antagonist. U-99194 inhibits the activation of D3 receptor mediated by endogenously released dopamine or exogenous D3 agonists. U-99194 abrogates the IPSC-suppressive effect of the D3 agonist PD 128907 in rat hippocampal slices. U-99194 significantly suppresses Nicotine -induced tremor in mice. U-99194 can be used for the study of dopamine D3 receptor-mediated motor disorders, particularly kinetic tremors[1][2].
CAS Number
82668-33-5
Product Name Alternative
U-99194A (free base) ; PNU-99194A; JPC-211
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/u-99194.html
Solubility
10 mM in DMSO
Smiles
CCCN(CCC)C1CC2=C(C=C(OC)C(OC)=C2)C1
Molecular Formula
C17H27NO2
Molecular Weight
277.40
References & Citations
[1]Kato M, et al. Mechanisms Underlying Dopaminergic Regulation of Nicotine-Induced Kinetic Tremor. Front Pharmacol. 2022 Jun 16;13:938175. |[2]Hammad H, et al. Dopamine-mediated disinhibition in the CA1 region of rat hippocampus via D3 receptor activation. J Pharmacol Exp Ther. 2006 Jan;316 (1) :113-20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D3 Receptor

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