BMS-814580

• UNSPSC Description:

  BMS-814580 is an orally active, highly efficacious MCHR1 inhibitor with a Ki of 16.9 nM against hMCHR1. BMS-814580 shows antiobesity activities[1].

• Target Antigen:

  MCHR1 (GPR24)

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/bms-814580.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C2=C(N=CN1C3=CC=C(OCC4(O)CC(C4)(F)F)C(OC)=C3)C=C(S2)C5=CC=C(C=C5)Cl

• Molecular Weight:

  504.93

• References & Citations:

  [1]Ahmad S, et al. Synthesis and Antiobesity Properties of 6-(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one (BMS-814580): A Highly Efficacious Melanin Concentrating Hormone Receptor 1 (MCHR1) Inhibitor. J Med Chem. 2016 Oct 13;59(19):8848-8858.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1197420-11-3