BMS-814580

• Description:

  BMS-814580 is an orally active, highly efficacious MCHR1 inhibitor with a Ki of 16.9 nM against hMCHR1. BMS-814580 shows antiobesity activities[1].

• UNSPSC:

  12352005

• Target:

  MCHR1 (GPR24)

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/bms-814580.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C2=C(N=CN1C3=CC=C(OCC4(O)CC(C4)(F)F)C(OC)=C3)C=C(S2)C5=CC=C(C=C5)Cl

• Molecular Formula:

  C24H19ClF2N2O4S

• Molecular Weight:

  504.93

• References & Citations:

  [1]Ahmad S, et al. Synthesis and Antiobesity Properties of 6- (4-Chlorophenyl) -3- (4- ((3,3-difluoro-1-hydroxycyclobutyl) methoxy) -3-methoxyphenyl) thieno[3,2-d]pyrimidin-4 (3H) -one (BMS-814580) : A Highly Efficacious Melanin Concentrating Hormone Receptor 1 (MCHR1) Inhibitor. J Med Chem. 2016 Oct 13;59 (19) :8848-8858.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1197420-11-3]