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SC-22716

CAT: 0804-HY-118795-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118795-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SC-22716 is a potent, competitive, reversible inhibitor of human LTA4 hydrolase, with an IC50 of 0.20 µM. SC-22716 has potential for the research of inflammatory bowel disease (IBD) and psoriasis[1].
CAS Number
262451-89-8
UNSPSC
12352005
Target
Aminopeptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sc-22716.html
Solubility
10 mM in DMSO
Smiles
N1(CCCC1)CCOC2=CC=C(C=C2)C3=CC=CC=C3
Molecular Formula
C18H21NO
Molecular Weight
267.37
References & Citations
[1]Penning TD, et, al. Structure-activity relationship studies on 1-[2- (4-Phenylphenoxy) ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A (4) (LTA (4) ) hydrolase. J Med Chem. 2000 Feb 24;43 (4) :721-35.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

SC 27716

inhibits leukotriene A4 hydrolase; structure in first source

CAS Number262451-89-8
PubChem CID10333202
IUPAC Name1-[2-(4-phenylphenoxy)ethyl]pyrrolidine
Molecular FormulaC18H21NO
Molecular Weight267.4
XLogP4
Topological Polar Surface Area12.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count5
Heavy Atom Count20
Formal Charge0
Complexity261
SMILES
C1CCN(C1)CCOC2=CC=C(C=C2)C3=CC=CC=C3
InChI
InChI=1S/C18H21NO/c1-2-6-16(7-3-1)17-8-10-18(11-9-17)20-15-14-19-12-4-5-13-19/h1-3,6-11H,4-5,12-15H2
InChIKey
PKUGRVAJRGZDJP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of SC 27716
CAS: 262451-89-8
CID: 10333202
Formula: C18H21NO
MW: 267.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight267.4
XLogP34
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count5
Exact Mass267.162314293
Monoisotopic Mass267.162314293
Topological Polar Surface Area12.5 Ų
Heavy Atom Count20
Formal Charge0
Complexity261
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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