SC-45662

• Description :

  SC-45662 is a 5-lipoxygenase inhibitor. SC-45662 inhibits the response of monocytes to phytohemagglutinin (PHA) . SC-45662 inhibits superoxide production in neutrophils. SC-45662 slows early changes in lung mechanics and pulmonary hypertension in a sheep model of impaired lung function. SC-45662 can be used in research on diseases of the immune system, respiratory system, etc[1][2][3].

• UNSPSC :

  12352005

• Target :

  Lipoxygenase

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Smiles :

  O=C(O)CO[C@@H](C)[C@H](SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)C

• Molecular Formula :

  C20H32O4S

• Molecular Weight :

  368.53

• References & Citations :

  [1]Weir MR, et al. The immunosuppressive properties of enisoprost and a 5-lipoxygenase inhibitor (SC-45662) . Transplantation. 1991 Dec;52 (6) :1053-7.|[2]Kocan GP, et al. Contrasting effects of two arachidonate 5-lipoxygenase inhibitors on formyl-methionyl-leucyl-phenylalanine (fMLP) and complement fragment 5a induced human neutrophil superoxide generation. Biochem Pharmacol. 1994 Mar 15;47 (6) :1029-37. |[3]Kuratomi Y, et al. Effect of a 5-lipoxygenase inhibitor on endotoxin-induced pulmonary dysfunction in awake sheep. J Appl Physiol (1985) . 1993 Feb;74 (2) :596-605.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [135133-84-5]