SC-435

CAT: 0804-HY-129982-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-129982-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
SC-435 is an orally effective apical sodium codependent bile acid transporter (ASBT) inhibitor. SC-435 effectively removes neurotoxic bile acids and ammonia from the blood by inhibiting intestinal ASBT, thereby alleviating liver and brain damage caused by liver failure. SC-435 can alter hepatic cholesterol metabolism and lower plasma low-density lipoprotein-cholesterol concentrations[1] [2] [3].
CAS Number
[289037-67-8]
UNSPSC
12352005
Target
Apical Sodium-Dependent Bile Acid Transporter
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sc-435.html
Purity
99.14
Solubility
DMSO : ≥ 50 mg/mL
Smiles
CS(=O)([O-])=O.O[C@@H]1[C@@](C2=CC=C(C=C2)OCCCC[N+]34CCN(CC4)CC3)([H])C5=CC(N(C)C)=CC=C5S(=O)(CC1(CCCC)CCCC)=O
Molecular Formula
C37H59N3O7S2
Molecular Weight
722.01
References & Citations
[1]West KL, et, al. 1-[4-[4[ (4R,5R) -3,3-Dibutyl-7- (dimethylamino) -2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl]phenoxy]butyl]-4-aza-1-azoniabicyclo[2.2.2]octane methanesulfonate (SC-435), an ileal apical sodium-codependent bile acid transporter inhibitor alters hepatic cholesterol metabolism and lowers plasma low-density lipoprotein-cholesterol concentrations in guinea pigs. J Pharmacol Exp Ther. 2002 Oct;303 (1) :293-9.|[2]Xie G, et al. Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure. EBioMedicine. 2018 Nov;37:294-306.|[3]West KL, et al. SC-435, an ileal apical sodium-codependent bile acid transporter inhibitor alters mRNA levels and enzyme activities of selected genes involved in hepatic cholesterol and lipoprotein metabolism in guinea pigs. J Nutr Biochem. 2005 Dec;16 (12) :722-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-136268-01AQX-435
HY-W953202CRBN ligand-435
HY-123747SC-53116
HY-120586SC-46944
HY-112739SC-41930
HY-112333SC-68376
HY-W717425SC-60
HY-105894SC-42867
HY-10828SC-57461
HY-107410-01SC-26196

Alternative Products

CatalogName
BA6550-5SC-435
MBS5778377SC-435 mesylate
BA3032-1AQX-435
sc-51694SC (SC-05)
MD023023-12SC-PEG12-SC
ABC-RC211DGFP-Human MDA-MB-435(MDA-MB-435)
PH2000745-01435 tNGS Panel
HO023023-500-01SC-PEG-SC, 500
HO023023-4K-01SC-PEG-SC, 4K
HO023023-1K-01SC-PEG-SC, 1K

Popular Products