SC-919

• Description :

  SC-919 (LI-2124) is an orally active and selective inhibitor targeting inositol hexakisphosphate kinases (IP6K, including IP6K1, IP6K2, and IP6K3 subtypes) with an IC50 value of 0.65 nM for IP6K3. SC-919 reduces the production of inositol pyrophosphates (e.g., InsP₇) by inhibiting IP6K, thereby suppressing XPR1-mediated cellular phosphate export and increasing intracellular ATP levels. SC-919 is promising for research of chronic kidney disease (CKD) -related hyperphosphataemia[1].

• CAS Number :

  [2245949-62-4]

• Product Name Alternative :

  LI-2124

• UNSPSC :

  12352005

• Target :

  IPK Superfamily

• Related Pathways :

  Metabolic Enzyme/Protease; PI3K/Akt/mTOR

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Smiles :

  O=C1[C@@]2(CC[C@@H](CC2)OC3=C(C=C(C=N3)Cl)Cl)C4=CC(C(O)=O)=CC=C4N1

• Molecular Formula :

  C19H16Cl2N2O4

• Molecular Weight :

  407.25

• References & Citations :

  [1]Moritoh Y, et al. The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals. Nat Commun. 2021 Aug 11;12 (1) :4847.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Inositol hexakisphosphate kinase