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SC-919

CAT: 0804-HY-171099Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-171099Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SC-919 (LI-2124) is an orally active and selective inhibitor targeting inositol hexakisphosphate kinases (IP6K, including IP6K1, IP6K2, and IP6K3 subtypes) with an IC50 value of 0.65 nM for IP6K3. SC-919 reduces the production of inositol pyrophosphates (e.g., InsP₇) by inhibiting IP6K, thereby suppressing XPR1-mediated cellular phosphate export and increasing intracellular ATP levels. SC-919 is promising for research of chronic kidney disease (CKD) -related hyperphosphataemia[1].
CAS Number
[2245949-62-4]
Product Name Alternative
LI-2124
UNSPSC
12352005
Target
IPK Superfamily
Related Pathways
Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=C1[C@@]2(CC[C@@H](CC2)OC3=C(C=C(C=N3)Cl)Cl)C4=CC(C(O)=O)=CC=C4N1
Molecular Formula
C19H16Cl2N2O4
Molecular Weight
407.25
References & Citations
[1]Moritoh Y, et al. The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals. Nat Commun. 2021 Aug 11;12 (1) :4847.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Inositol hexakisphosphate kinase

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