SC-43

• UNSPSC Description:

  SC-43, a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist. SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis. SC-43 has anti-fibrotic and anticancer effects[1][2].

• Target Antigen:

  Apoptosis; Phosphatase; STAT

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;JAK/STAT Signaling;Metabolic Enzyme/Protease;Stem Cell/Wnt

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sc-43.html

• Smiles:

  O=C(NC1=CC=CC(OC2=CC=C(C#N)C=C2)=C1)NC3=CC=C(Cl)C(C(F)(F)F)=C3

• Molecular Weight:

  431.80

• References & Citations:

  [1]Ming-Hung Hu, et al. Targeting SHP-1-STAT3 signaling: A promising therapeutic approach for the treatment of cholangiocarcinoma. Oncotarget. 2017 May 10;8(39):65077-65089.|[2]Tung-Hung Su, et al. Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis. Sci Rep. 2017 May 11;7(1):1728.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  1400989-25-4