BMS-901715

• Description :

  BMS-901715 is a potent and selective adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 of 3.3 nM[1][2].

• UNSPSC :

  12352005

• Target :

  AAK1

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/bms-901715.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC1=CC(C2=NN(C(C)C)N=N2)=CC(NC3=NC=NN4C3=C(CN5CCC(N)CC5)C=C4)=C1

• Molecular Formula :

  C22H28N10O

• Molecular Weight :

  448.52

• References & Citations :

  [1]Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358 (3) :371-86.|[2]Carolyn Diane Dzierba, et al. Pyrrolotriazine kinase inhibitors. WO2015054358A1.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1699861-37-4]