MI-1481

CAT: 0804-HY-117365Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-117365Size:1 Each
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Description
MI-1481 is a highly potent inhibitor of the Menin-MLL1 interaction with IC50 of 3.6 nM. MI-1481 markedly reduces cell growth of murine bone marrow cells transformed and inhibits leukemia progression[1].
CAS Number
[1887178-64-4]
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mi-1481.html
Solubility
10 mM in DMSO
Smiles
N#CC(N1C[C@@H](OC2)CNC2=O)=CC3=C1C=CC(CN4CCC(NC5=C(C=C(CC(F)(F)F)S6)C6=NC=N5)CC4)=C3C
Molecular Formula
C29H30F3N7O2S
Molecular Weight
597.65
References & Citations
[1]Borkin D, et.al. Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction. J Med Chem. 2018 Jun 14;61 (11) :4832-4850.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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