MI-773

• Description:

  MI-773 is a potent MDM2-p53 protein‐protein interaction (PPI) inhibitor with high binding affinity against MDM2 (Kd=8.2 nM) . MI-773 has antitumor activity[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H320, H335

• Target:

  E1/E2/E3 Enzyme; MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/MI-773.html

• Concentration:

  10mM

• Purity:

  98.0

• Solubility:

  DMSO : ≥ 53 mg/mL

• Smiles:

  O=C([C@H](N[C@@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2F)[C@]31C(NC4=C3C=CC(Cl)=C4)=O)N[C@H]5CC[C@H](O)CC5

• Molecular Formula:

  C29H34Cl2FN3O3

• Molecular Weight:

  562.50

• Precautions:

  H302, H315, H320, H335

• References & Citations:

  [1]Zhang Q, et al. Targeting p53-MDM2-MDMX loop for cancer therapy. Subcell Biochem. 2014;85:281-319.|[2]Tatyana A Grigoreva, et al. Amino acids as chiral derivatizing agents for antiproliferative substituted N-benzyl isoindolinones. Chirality. 2018 Jun;30 (6) :785-797.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1303607-07-9]