MI-1063

CAT: 0804-HY-133754Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-133754Size:1 Each
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Description
MI-1063 is an inhibitor for DMD-2, that blocks the MDM2-p53 interaction, and activates the tumor suppressor function of p53. MI-1063 inhibits the growth of cancer cell RS4-11 and MV4-11 with IC50 of 179 nM and 93 nM. MI-1063 can be used as target protein ligand in synthesis of PROTAC degrader MD-265 (HY-169327) [1].
CAS Number
[1410737-39-1]
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mi-1063.html
Smiles
O=C(O)[C@H]1CC[C@@H](CC1)NC([C@@H]2NC3(CCCCC3)[C@]4(C5=CC=C(C=C5NC4=O)Cl)[C@H]2C6=CC=CC(Cl)=C6F)=O
Molecular Formula
C30H32Cl2FN3O4
Molecular Weight
588.50
References & Citations
[1]Aguilar A, et al., Discovery of MD-265: A Potent MDM2 Degrader That Achieves Complete Tumor Regression and Improves Long-Term Survival of Mice with Leukemia. J Med Chem. 2024 Nov 14;67 (21) :19503-19518.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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