MI-1063

• UNSPSC Description:

  MI-1063 is an inhibitor for DMD-2, that blocks the MDM2-p53 interaction, and activates the tumor suppressor function of p53. MI-1063 inhibits the growth of cancer cell RS4-11 and MV4-11 with IC50 of 179 nM and 93 nM. MI-1063 can be used as target protein ligand in synthesis of PROTAC degrader MD-265 (HY-169327)[1].

• Target Antigen:

  Ligands for Target Protein for PROTAC; MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mi-1063.html

• Smiles:

  O=C(O)[C@H]1CC[C@@H](CC1)NC([C@@H]2NC3(CCCCC3)[C@]4(C5=CC=C(C=C5NC4=O)Cl)[C@H]2C6=CC=CC(Cl)=C6F)=O

• Molecular Weight:

  588.50

• References & Citations:

  [1]Aguilar A, et al., Discovery of MD-265: A Potent MDM2 Degrader That Achieves Complete Tumor Regression and Improves Long-Term Survival of Mice with Leukemia. J Med Chem. 2024 Nov 14;67(21):19503-19518.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1410737-39-1