MI 14

• Description:

  MI 14 is a selective PI4KIIIβ inhibitor with IC50s of 54 nM, >100 μM, >100 μM for PI4KIIIβ, PI4KIIIα, PI4KIIα, respectively. MI 14 has antiviral activity against HCV 1b, CVB3, HRVM, HVC 2a[1].

• UNSPSC:

  12352005

• Target:

  HCV; PI4K

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; PI3K/Akt/mTOR

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/mi-14.html

• Purity:

  99.30

• Solubility:

  DMSO : 9.02 mg/mL (ultrasonic; warming)

• Smiles:

  O=C(C)NCCNC1=CC(Cl)=NN2C1=NC(C)=C2C3=CC(S(=O)(N(C)C)=O)=CC=C3

• Molecular Formula:

  C19H23ClN6O3S

• Molecular Weight:

  450.94

• References & Citations:

  [1]Ivana Mejdrová, et al. Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action. J Med Chem. 2015 May 14;58 (9) :3767-93.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PI4KII; PI4KIIIα; PI4KIIIβ

• CAS Number:

  [1715934-43-2]