MI 14

• Description :

  MI 14 is a selective PI4KIIIβ inhibitor with IC50s of 54 nM, >100 μM, >100 μM for PI4KIIIβ, PI4KIIIα, PI4KIIα, respectively. MI 14 has antiviral activity against HCV 1b, CVB3, HRVM, HVC 2a[1].

• CAS Number :

  [1715934-43-2]

• UNSPSC :

  12352005

• Target :

  HCV; PI4K

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; PI3K/Akt/mTOR

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/mi-14.html

• Purity :

  99.30

• Solubility :

  DMSO : 9.02 mg/mL (ultrasonic; warming)

• Smiles :

  O=C(C)NCCNC1=CC(Cl)=NN2C1=NC(C)=C2C3=CC(S(=O)(N(C)C)=O)=CC=C3

• Molecular Formula :

  C19H23ClN6O3S

• Molecular Weight :

  450.94

• References & Citations :

  [1]Ivana Mejdrová, et al. Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action. J Med Chem. 2015 May 14;58 (9) :3767-93.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PI4KII; PI4KIIIα; PI4KIIIβ