TPE-MI

• Description :

  TPE-MI (Tetraphenylethene maleimide) is a thiol probe for measuring unfolded protein load and proteostasis in cells (the excitation wavelength is 350 nm and the emission wavelength is 470 nm) . TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasitesPlasmodium falciparum [1][2].

• CAS Number :

  [1245606-71-6]

• Product Name Alternative :

  Tetraphenylethene maleimide

• UNSPSC :

  12171500

• Hazard Statement :

  H302, H315, H319

• Target :

  Huntingtin; Parasite

• Type :

  Dye Reagents

• Related Pathways :

  Anti-infection; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Infection; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/tpe-mi.html

• Purity :

  98.93

• Solubility :

  DMSO : 8.57 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(C=C1)N(C2=CC=C(/C(C3=CC=CC=C3)=C(C4=CC=C(C)C=C4)/C5=CC=CC=C5)C=C2)C1=O

• Molecular Formula :

  C31H23NO2

• Molecular Weight :

  441.52

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Chen MZ, et al. A thiol probe for measuring unfolded protein load and proteostasis in cells. Nat Commun. 2017;8 (1) :474. Published 2017 Sep 7. |[2]Hu Q, et al. In Situ Monitored Vortex Fluidic-Mediated Protein Refolding/Unfolding Using an Aggregation-Induced Emission Bioprobe. Molecules. 2021;26 (14) :4273. Published 2021 Jul 14.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Dye Reagents

• Clinical Information :

  No Development Reported

• Isoform :

  Plasmodium