MI-192

• UNSPSC Description:

  MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC50s of 30 nM and 16 nM, respectively. MI-192 is more selective for HDAC2/3 than other HDAC isomers.MI-192 induces myeloid leukaemic cells apoptosis. Anticaner and neuroprotective activities[1][2].

• Target Antigen:

  Apoptosis; HDAC

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/mi-192.html

• Purity:

  99.0

• Solubility:

  DMSO : 5 mg/mL (ultrasonic;warming)

• Smiles:

  O=C1C2=CC=CC=C2C(CN1CC3=CC=C(C(NC4=C(C=CC=C4)N)=O)C=C3)=C

• Molecular Weight:

  383.44

• References & Citations:

  [1]Marjorie Boissinot, et al. Induction of differentiation and apoptosis in leukaemic cell lines by the novel benzamide family histone deacetylase 2 and 3 inhibitor MI-192. Leuk Res. 2012 Oct;36(10):1304-10.|[2]S V Demyanenko, et al. The Neuroprotective Effect of the HDAC2/3 Inhibitor MI192 on the Penumbra After Photothrombotic Stroke in the Mouse Brain. Mol Neurobiol. 2020 Jan;57(1):239-248.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1415340-63-4