MI-463

• Description :

  MI-463 is a highly potent and orally bioavailable small molecule inhibitor of the menin-mLL interaction.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Epigenetic Reader Domain

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/MI-463.html

• Purity :

  99.66

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  FC(F)(F)CC(S1)=CC2=C1N=CN=C2NC3CCN(CC4=CC=C(NC(C#N)=C5)C5=C4C)CC3

• Molecular Formula :

  C24H23F3N6S

• Molecular Weight :

  484.54

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Borkin D, et al. Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo. Cancer Cell. 2015 Apr 13;27 (4) :589-602.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1628317-18-9]